Immunotherapy, also called biologic therapy, is a type of cancer
treatment that boosts the body's natural defenses to fight cancer.
It uses substances made by the body or in a laboratory to improve
or restore immune system function.
Immunotherapy may work by:Stopping or slowing the growth of cancer cells
Stopping cancer from spreading to other parts of the body
Helping the immune system work better at destroying cancer cells
Types of immunotherapies
There are three main types of adoptive cellular therapy:
- 1.Immune checkpoint therapy helps cancer-fighting
immune cells, called T cells, mount a longer-lasting response
against the cancer. Eg.Pembrolizumab, Nivolumab, Atezolizumab,
- 2.Adoptive cellular therapy increases the number and/or effectiveness of immune cells, usually T cells, which improves the power of the immune response against the cancer.
- a.Chimeric Antigen Receptor (CAR) T-cell therapy gives patients large amounts of T cells that are all genetically engineered to find and fight the cancer.
- b.Tumor infiltrating lymphocyte (TIL) therapy uses a patient’s T cells that are collected from a piece of surgically-removed tumor. While these cells may recognize the cancer, there are too few of them to succeed. The number of these cells is increased substantially in the lab and then given back to the patient.
- c.Endogenous T-cell (ETC) therapy uses T cells from a patient’s blood. From this diverse pool of T cells, doctors select only those that may recognize signatures specific to the cancer. The number of these specific T cells is increased substantially and then given back to the patient.