- Allogeneic bone marrow transplant. The term allo means self. Stem cells are removed from another person, called a donor. Most times, the donor’s genes must at least partly match patients genes. Special tests are done to see if a donor is a good match. A brother or sister is most likely to be a good match. Sometimes parents, children and other relatives are good matches. Donors who are not related to you, yet still match, may be found through national bone marrow registries.
The stem cells are delivered into your bloodstream usually through a tube called a central venous catheter. The process is similar to getting a blood transfusion. The stem cells travel through the blood into the bone marrow.
Donor stem cells can be collected in two ways:
- Bone marrow harvest. This minor surgery is done under general anesthesia. This means the donor will be asleep and pain-free during the procedure. The bone marrow is removed from the back of both hip bones. The amount of marrow removed depends on the weight of the person who is receiving it.
- Leukapheresis :First, the donor is given several days of Growth Factor injections to help stem cells increase and move from the bone marrow into the blood. The donor is then connected to a leukapheresis machine where the person’s blood is continually being circulated and WBCs are filtered ( similar to the setup when a person is giving blood for SDP platelets in blood bank). The part of white blood cells that contains stem cells is then separated in a machine and filtered out to be later given to the recipient. The red blood cells are returned to the donor.
- Bone marrow transplantations are used to treat people with certain diseases like
- Multiple myeloma